Across TCGA cell cohorts, APOBR mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBR-associated genes across cancer lineages are ATE1, AGXT2, and RAB3IP. Each is linked with APOBR in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBR-to-partner and partner-to-APOBR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBR→partner) and Y-score (partner→APOBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATE1 →	+0.841	+3.064	<.001	.009	3	1
LARGE_INTESTINE	AGXT2 →	+0.014	+2.560	.009	.008	3	1
LARGE_INTESTINE	RAB3IP →	+0.647	+3.215	.004	.009	3	1
LARGE_INTESTINE	HCN4 →	+0.240	+2.900	<.001	.002	3	1
LARGE_INTESTINE	HSPD1 →	+0.697	+3.125	<.001	.008	3	1
LARGE_INTESTINE	PTH →	+0.039	+2.777	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

APOBR survival (RNA) · tumor vs normal (RNA) · all APOBR data types