APOBEC4

Across TCGA patient cohorts, APOBEC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,319 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible APOBEC4-associated proteins across cancer lineages are TPPP3, TRAF3IP1, and PLOD1. Each is linked with APOBEC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both APOBEC4-to-partner and partner-to-APOBEC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC4 versus TPPP3 in UCEC, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC4→partner) and Y-score (partner→APOBEC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPPP3 →	+1.787	+1.569	<.001	<.001	3	5
LSCC	TRAF3IP1 →	+0.456	+0.593	<.001	<.001	3	5
UCEC	PLOD1 →	-0.452	-1.179	<.001	<.001	3	4
UCEC	RPGR_S961 →	+0.644	+1.433	<.001	<.001	3	4
OV	RSPH3_T243 →	+1.520	+1.762	.003	.003	3	4
UCEC	SPA17 →	+0.939	+1.354	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,319 associations by consensus.

APOBEC4 vs TPPP3 — UCEC

Explore this scatter interactively →