APOBEC4

Across TCGA pan-cancer cohorts, APOBEC4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated APOBEC4 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher APOBEC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOBEC4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CESC show a favorable association.

KICH, KIRP, and PAAD are the cancer types where APOBEC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.590	0.938	<.001	69	view →
KIRP	OS	Tertile	III,IV	0.378	0.817	<.001	60	view →
PAAD	DFS	Tertile	All	0.422	0.192	.001	56	view →
CESC	DFS	Tertile	II,III,IV	0.855	0.624	.006	56	view →
BRCA	OS	Tertile	II,III,IV	0.648	0.516	.007	52	view →
LIHC	DFS	Tertile	All	0.408	0.568	.003	30	view →
HNSC	OS	Tertile	III,IV	0.840	0.701	.012	27	view →
BLCA	DFS	Quartile	III,IV	0.125	0.361	.001	23	view →
SKCM	DFS	Tertile	IV	0.040	0.620	.003	20	view →
READ	OS	Median	All	0.920	0.720	.006	20	view →
STAD	OS	Tertile	III,IV	0.343	0.664	.018	15	view →
THCA	DFS	Tertile	IV	0.189	0.839	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

APOBEC4–KICH (DFS)

Open the KICH breakdown →