APOBEC4

Across TCGA patient cohorts, APOBEC4 mutation is significantly associated with the RNA expression of many other genes, with 844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC4-associated genes across cancer lineages are LINC01072, RNA5SP73, and RN7SKP135. Each is linked with APOBEC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC4-to-partner and partner-to-APOBEC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by APOBEC4-low versus APOBEC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC4→partner) and Y-score (partner→APOBEC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.163	+2.614	<.001	.001	3	2
CESC	RNA5SP73 →	+0.443	+6.837	<.001	<.001	3	2
BRCA	RN7SKP135 →	+0.098	+7.731	<.001	.009	3	1
BRCA	RNA5SP102 →	+0.217	+8.055	<.001	.007	3	1
BLCA	SLC20A1P3 →	+0.049	+7.640	<.001	.009	3	1
BLCA	OR4G6P →	+0.044	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 844 associations by consensus.

LINC01072 by APOBEC4 expression — UCEC

Explore this box plot interactively →