APOBEC4

Across TCGA patient cohorts, APOBEC4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC4-associated genes across cancer lineages are Annexin-1, TIGAR, and CD49b. Each is linked with APOBEC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC4-to-partner and partner-to-APOBEC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by APOBEC4-low versus APOBEC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC4→partner) and Y-score (partner→APOBEC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.817	+3.700	<.001	.001	3	2
UCEC	TIGAR →	+0.208	+1.901	.003	.031	3	1
UCEC	CD49b →	-0.357	-3.302	.007	.010	3	1
UCEC	Cyclin-D1 →	+0.154	+3.169	.041	.018	3	1
UCEC	Di-Ras3 →	-0.141	-2.584	.042	.011	3	1
UCEC	ACC1 →	+0.339	+2.584	.045	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Annexin-1 by APOBEC4 expression — UCEC

Explore this box plot interactively →