APOBEC4

Across TCGA cell cohorts, APOBEC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,026 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APOBEC4-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Signal transduction in response to DNA damage, and Regulation of protein localization to chromatin. Each is linked with APOBEC4 in more than 5 cancer types. Because this analysis shows association rather than direction, both APOBEC4-to-partner and partner-to-APOBEC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by APOBEC4-low versus APOBEC4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC4→partner) and Y-score (partner→APOBEC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.136	+0.023	.005	.002	2	6
BONE	Signal transduction in response to DNA damage →	+0.081	+0.026	.001	.001	3	5
BLOOD_Leukemia	Regulation of protein localization to chromatin →	+0.048	+0.030	.002	.004	3	5
CNS	Negative regulation of cell projection organization →	+0.045	+0.024	<.001	.001	3	4
BONE	Cytoplasm protein quality control →	+0.148	+0.030	<.001	.001	3	4
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.095	+0.022	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,026 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by APOBEC4 expression — BONE

Explore this box plot interactively →