APOBEC4

Across TCGA cell cohorts, APOBEC4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible APOBEC4-associated genes across cancer lineages are MAGEB5 and H4C7. Each is linked with APOBEC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC4-to-partner and partner-to-APOBEC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by APOBEC4-low versus APOBEC4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC4→partner) and Y-score (partner→APOBEC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	H4C7 →	+0.389	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MAGEB5 by APOBEC4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →