APOBEC3F

Across TCGA pan-cancer cohorts, APOBEC3F mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated APOBEC3F data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher APOBEC3F mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOBEC3F expression acts as an unfavorable survival marker.

UCEC, GBM, and OV are the cancer types where APOBEC3F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.368	1.000	.004	32	view →
GBM	DFS	Tertile	All	0.243	0.613	.023	12	view →
OV	DFS	Median	All	0.484	0.819	.039	8	view →
PDAC	OS	Quartile	III,IV	0.216	0.835	.006	6	view →
LSCC	DFS	Tertile	II,III,IV	0.513	0.816	.027	6	view →
CCRCC	OS	Tertile	IV	0.125	0.789	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

APOBEC3F–UCEC (DFS)

Open the UCEC breakdown →