APOBEC3F

Across TCGA pan-cancer cohorts, APOBEC3F mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of APOBEC3F’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where APOBEC3F mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC3F is over-expressed in tumor.

CCRCC, LSCC, and LUAD are the cancer types where APOBEC3F tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3F mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.903	<.001	12	view →
LSCC	Male	All	+0.360	<.001	7	view →
LUAD	Male	All	+0.225	<.001	7	view →
PDAC	All	All	+0.285	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

APOBEC3F–CCRCC

Open the CCRCC breakdown →