APOBEC3D

Across TCGA pan-cancer cohorts, APOBEC3D Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated APOBEC3D data layer compared with 25 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher APOBEC3D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated APOBEC3D expression acts as an unfavorable survival marker.

COAD, SKCM, and LIHC are the cancer types where APOBEC3D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.144	0.618	<.001	33	view →
SKCM	OS	Median	All	0.520	0.789	.004	20	view →
LIHC	DFS	Median	All	0.083	0.555	<.001	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

APOBEC3D–COAD (OS)

Open the COAD breakdown →