APOBEC3C

Across TCGA patient cohorts, APOBEC3C protein abundance is significantly associated with the RNA expression of many other genes, with 15,261 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOBEC3C-associated genes across cancer lineages are RAC2, APOBEC3G, and FYB1. Each is linked with APOBEC3C in more than 8 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC3C versus RAC2 in BRCA, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAC2 →	+0.963	+0.654	<.001	<.001	3	9
COAD	APOBEC3G →	+1.071	+0.571	<.001	<.001	3	9
LSCC	FYB1 →	+0.922	+0.373	<.001	<.001	3	8
COAD	APOBEC3F →	+0.699	+0.669	<.001	<.001	3	7
BRCA	IL2RB →	+0.984	+0.494	<.001	<.001	3	7
GBM	JAK3 →	+1.022	+0.703	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,261 associations by consensus.

APOBEC3C vs RAC2 — BRCA

Explore this scatter interactively →