APOBEC3C

Across TCGA patient cohorts, APOBEC3C protein abundance is significantly associated with the protein abundance of many other proteins, with 21,473 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOBEC3C-associated proteins across cancer lineages are VAV1, ARHGAP45, and SH3BP1. Each is linked with APOBEC3C in more than 8 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC3C versus VAV1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VAV1 →	+0.654	+0.662	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.606	+0.596	<.001	<.001	3	9
LSCC	SH3BP1 →	+0.370	+0.483	<.001	<.001	3	8
LSCC	STK10 →	+0.372	+0.382	<.001	<.001	3	8
HNSC	LCP2 →	+0.544	+0.671	<.001	<.001	3	8
BRCA	ARHGAP25 →	+0.542	+0.737	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,473 associations by consensus.

APOBEC3C vs VAV1 — GBM

Explore this scatter interactively →