APOBEC3C

Across TCGA patient cohorts, APOBEC3C mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3C-associated genes across cancer lineages are NUTF2P8, RN7SKP169, and RNMTL1P2. Each is linked with APOBEC3C in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTF2P8 grouped by APOBEC3C-low versus APOBEC3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2P8 →	+0.174	+3.246	<.001	.008	3	2
COAD	RN7SKP169 →	+0.118	+4.070	.007	.009	3	2
COAD	RNMTL1P2 →	+0.124	+4.707	<.001	<.001	3	2
UCEC	RNU6-1318P →	+0.581	+3.621	<.001	.004	3	2
UCEC	TRAJ18 →	+0.999	+2.958	<.001	.005	3	2
UCEC	CSN1S2AP →	+0.108	+3.246	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

NUTF2P8 by APOBEC3C expression — UCEC

Explore this box plot interactively →