APOBEC3C

Across TCGA patient cohorts, APOBEC3C mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3C-associated genes across cancer lineages are aDC, CD8+ T-cells, and CD8+ Tcm. Each is linked with APOBEC3C in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by APOBEC3C-low versus APOBEC3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.113	+2.818	.012	.037	3	1
UCEC	CD8+ T-cells →	+0.030	+3.845	<.001	<.001	3	1
UCEC	CD8+ Tcm →	+0.052	+3.935	<.001	<.001	3	1
UCEC	B-cells →	+0.040	+2.310	.016	.026	3	1
UCEC	Sebocytes →	+0.034	+2.828	.024	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

aDC by APOBEC3C expression — UCEC

Explore this box plot interactively →