APOBEC3C

Across TCGA cell cohorts, APOBEC3C protein abundance is significantly associated with the go_rna of many other GO terms, with 648 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible APOBEC3C-associated GO terms across cancer lineages are Macrophage activation, Positive regulation of secretion by cell, and Actin nucleation. Each is linked with APOBEC3C in more than 3 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophage activation grouped by APOBEC3C-low versus APOBEC3C-high in OVARY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Macrophage activation →	-0.075	-1.201	.001	.005	3	4
LUNG_NSCLC_LUAD	Positive regulation of secretion by cell →	-0.049	-0.973	.005	.009	3	3
BLOOD_Leukemia	Actin nucleation →	+0.154	+0.851	<.001	.009	3	3
BLOOD_Lymphoma	Regulatory ncRNA-mediated heterochromatin formation →	+0.091	+1.019	.002	.002	3	3
LUNG_SCLC	NAD+ metabolic process →	-0.158	-1.781	<.001	<.001	3	3
LUNG_SCLC	Regulation of stem cell division →	+0.167	+1.450	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

Macrophage activation by APOBEC3C expression — OVARY

Explore this box plot interactively →