APOBEC1

Across TCGA patient cohorts, APOBEC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,822 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible APOBEC1-associated GO terms across cancer lineages are Fructose metabolic process, Positive regulation of retinoic acid receptor signaling pathway, and Positive regulation of ryanodine-sensitive calcium-release channel activity. Each is linked with APOBEC1 in more than 10 cancer types. Because this analysis shows association rather than direction, both APOBEC1-to-partner and partner-to-APOBEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fructose metabolic process grouped by APOBEC1-low versus APOBEC1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC1→partner) and Y-score (partner→APOBEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Fructose metabolic process →	+0.056	+1.308	<.001	<.001	3	11
ESCA	Positive regulation of retinoic acid receptor signaling pathway →	+0.053	+1.082	<.001	<.001	3	11
ESCA	Positive regulation of ryanodine-sensitive calcium-release channel activity →	+0.072	+1.380	<.001	<.001	3	11
ESCA	Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway →	+0.050	+1.111	<.001	<.001	3	10
ESCA	Ribonucleoside diphosphate metabolic process →	+0.038	+0.934	<.001	<.001	3	10
KIRC	Nucleoside phosphate biosynthetic process →	+0.029	+0.061	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,822 associations by consensus.

Fructose metabolic process by APOBEC1 expression — ESCA

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