APOBEC1

Across TCGA patient cohorts, APOBEC1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC1-associated genes across cancer lineages are Myosin-IIa_pS1943, Myosin-IIa, and p62 Lck ligand. Each is linked with APOBEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC1-to-partner and partner-to-APOBEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by APOBEC1-low versus APOBEC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC1→partner) and Y-score (partner→APOBEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.243	+2.183	.024	.035	3	1
UCEC	Myosin-IIa →	+0.269	+3.329	.005	.005	3	1
UCEC	p62 Lck ligand →	+0.606	+3.321	<.001	.010	3	1
UCEC	PCNA →	+0.306	+3.169	.006	.019	3	1
UCEC	Rab25 →	-0.569	-3.321	.001	.010	3	1
UCEC	TIGAR →	+0.183	+2.196	.022	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Myosin-IIa_pS1943 by APOBEC1 expression — UCEC

Explore this box plot interactively →