APOBEC1

Across TCGA cell cohorts, APOBEC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC1-associated GO terms across cancer lineages are Regulation of clathrin coat assembly, Lateral line system development, and Anatomical structure homeostasis. Each is linked with APOBEC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both APOBEC1-to-partner and partner-to-APOBEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of clathrin coat assembly grouped by APOBEC1-low versus APOBEC1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC1→partner) and Y-score (partner→APOBEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of clathrin coat assembly →	+0.266	+1.191	<.001	.004	3	5
PANCREAS	Lateral line system development →	+1.761	+0.603	<.001	.004	3	4
LARGE_INTESTINE	Anatomical structure homeostasis →	+0.072	+1.049	<.001	<.001	3	4
LARGE_INTESTINE	Protein localization to postsynapse →	+0.101	+1.037	<.001	<.001	3	4
STOMACH	Chromosomal 5-methylcytosine DNA demethylation pathway →	-0.313	-1.557	<.001	<.001	3	4
LARGE_INTESTINE	Tissue homeostasis →	+0.072	+1.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

Regulation of clathrin coat assembly by APOBEC1 expression — STOMACH

Explore this box plot interactively →