APOB

Across TCGA pan-cancer cohorts, APOB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated APOB data layer compared with 29 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher APOB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where APOB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.244	1.000	.002	34	view →
PDAC	OS	Tertile	II,III,IV	0.330	0.633	.006	20	view →
CCRCC	DFS	Median	All	0.930	0.687	.001	16	view →
OV	DFS	Tertile	All	0.896	0.465	.035	12	view →
LUAD	OS	Tertile	II,III,IV	0.293	0.893	.007	10	view →
LSCC	OS	Quartile	All	0.936	1.000	.022	6	view →
GBM	OS	Quartile	All	0.992	0.703	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

APOB–UCEC (DFS)

Open the UCEC breakdown →