APOA5

Across TCGA patient cohorts, APOA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,705 significant associations in total. THCA shows the largest number of these associations.

The most reproducible APOA5-associated GO terms across cancer lineages are Regulation of very-low-density lipoprotein particle remodeling, Nucleoside bisphosphate metabolic process, and Positive regulation of triglyceride lipase activity. Each is linked with APOA5 in more than 11 cancer types. Because this analysis shows association rather than direction, both APOA5-to-partner and partner-to-APOA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of very-low-density lipoprotein particle remodeling grouped by APOA5-low versus APOA5-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA5→partner) and Y-score (partner→APOA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Regulation of very-low-density lipoprotein particle remodeling →	+0.557	+0.310	<.001	<.001	3	11
CHOL	Nucleoside bisphosphate metabolic process →	+0.061	+5.538	<.001	<.001	3	11
SARC	Positive regulation of triglyceride lipase activity →	-0.095	-0.116	<.001	.006	1	12
ESCA	Thioester biosynthetic process →	+0.036	+0.137	<.001	<.001	3	10
STAD	Mitochondrial translation →	+0.074	+0.260	<.001	.002	3	10
PAAD	Cytolysis by host of symbiont cells →	-0.112	-0.231	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,705 associations by consensus.

Regulation of very-low-density lipoprotein particle remodeling by APOA5 expression — TGCT

Explore this box plot interactively →