APOA5

Across TCGA pan-cancer cohorts, APOA5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of APOA5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where APOA5 RNA is repressed in tumor relative to normal tissue. In most cancer types APOA5 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where APOA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.436	<.001	9	view →
THCA	Male	All	−0.261	<.001	7	view →
LUSC	Female	All	−0.328	<.001	6	view →
UCEC	All	IV	+0.105	.019	6	view →
CHOL	Female	All	−8.833	<.001	5	view →
LIHC	All	All	−1.165	<.001	5	view →
BRCA	Female	II,III,IV	+0.048	.008	4	view →
KICH	All	All	−0.022	.002	4	view →
BLCA	All	All	+0.036	.036	2	view →
COAD	Male	All	+0.028	.033	2	view →
READ	All	All	+0.070	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

APOA5–LUAD

Open the LUAD breakdown →