APOA5

Across TCGA patient cohorts, APOA5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOA5-associated genes across cancer lineages are EGFR_pY1068, MEK1, and ATM. Each is linked with APOA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOA5-to-partner and partner-to-APOA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by APOA5-low versus APOA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA5→partner) and Y-score (partner→APOA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.265	-2.115	.015	.019	3	2
UCEC	MEK1 →	+0.492	+3.321	.002	.010	3	2
UCEC	ATM →	-0.569	-2.807	.004	.003	3	2
UCEC	4E-BP1 →	+0.359	+2.999	.002	.035	3	2
UCEC	eEF2K →	+0.379	+3.000	.012	.036	3	2
UCEC	FASN →	+0.458	+2.321	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by APOA5 expression — UCEC

Explore this box plot interactively →