APOA1-AS

Across TCGA pan-cancer cohorts, APOA1-AS RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated APOA1-AS data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher APOA1-AS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated APOA1-AS expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, ACC, and LGG are the cancer types where APOA1-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.418	0.241	.001	85	view →
ACC	DFS	Tertile	All	0.354	0.718	.001	52	view →
LGG	DFS	Median	All	0.674	0.795	<.001	39	view →
MESO	OS	Median	IV	0.283	0.748	.005	31	view →
UCS	DFS	Tertile	IV	0.975	0.333	.017	30	view →
LUSC	DFS	Tertile	II,III,IV	0.309	0.501	.006	26	view →
READ	OS	Tertile	III,IV	0.797	0.285	.006	26	view →
KIRC	DFS	Median	III,IV	0.620	0.316	.004	22	view →
UVM	DFS	Quartile	All	0.328	1.000	.016	16	view →
LUAD	DFS	Tertile	III,IV	0.807	0.512	.009	8	view →
SKCM	OS	Median	III,IV	0.852	0.739	.019	8	view →
THCA	DFS	Median	All	0.886	0.774	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

APOA1-AS–HNSC (DFS)

Open the HNSC breakdown →