APOA1-AS

Across TCGA pan-cancer cohorts, APOA1-AS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of APOA1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where APOA1-AS RNA is repressed in tumor relative to normal tissue. In most cancer types APOA1-AS is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where APOA1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOA1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.335	<.001	11	view →
LUSC	Female	II,III,IV	−1.172	<.001	9	view →
LUAD	Female	II,III,IV	−0.966	<.001	8	view →
UCEC	All	All	−0.449	<.001	8	view →
KICH	All	All	−0.323	<.001	6	view →
LIHC	Male	All	+0.309	<.001	6	view →
HNSC	All	II,III,IV	+0.109	.002	6	view →
COAD	All	III,IV	−0.348	<.001	4	view →
KIRP	All	All	−0.255	<.001	2	view →
KIRC	Male	II,III,IV	−0.153	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

APOA1-AS–THCA

Open the THCA breakdown →