APLN

Across TCGA patient cohorts, APLN mutation is significantly associated with the RNA expression of many other genes, with 1,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLN-associated genes across cancer lineages are CYFIP1, RN7SL248P, and RNA5SP414. Each is linked with APLN in more than 1 cancer types. Because this analysis shows association rather than direction, both APLN-to-partner and partner-to-APLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYFIP1 grouped by APLN-low versus APLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLN→partner) and Y-score (partner→APLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYFIP1 →	+0.526	+2.354	.004	.003	3	1
UCEC	RN7SL248P →	+0.067	+3.400	<.001	.003	3	1
UCEC	RNA5SP414 →	+0.477	+2.603	<.001	<.001	3	1
UCEC	TMEM269 →	+0.238	+2.354	<.001	.003	3	1
UCEC	ZNF280B →	+0.824	+4.098	<.001	<.001	3	1
UCEC	SYNRG →	+0.457	+3.032	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,712 associations by consensus.

CYFIP1 by APLN expression — UCEC

Explore this box plot interactively →