APLF

Across TCGA cell cohorts, APLF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,815 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible APLF-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Process utilizing autophagic mechanism, and Autophagy. Each is linked with APLF in more than 12 cancer types. Because this analysis shows association rather than direction, both APLF-to-partner and partner-to-APLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by APLF-low versus APLF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APLF→partner) and Y-score (partner→APLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.097	+0.773	.002	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.062	+0.476	.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.062	+0.476	.001	.004	3	12
SKIN	Positive regulation of protein K48-linked ubiquitination →	+0.125	+0.495	.003	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.073	+0.560	<.001	.001	3	11
URINARY_TRACT	COPII-coated vesicle budding →	+0.101	+0.712	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,815 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by APLF expression — OESOPHAGUS

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