API5

Across TCGA patient cohorts, API5 mutation is significantly associated with the RNA expression of many other genes, with 2,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible API5-associated genes across cancer lineages are RNA5SP73, RN7SL371P, and OR10AE1P. Each is linked with API5 in more than 2 cancer types. Because this analysis shows association rather than direction, both API5-to-partner and partner-to-API5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by API5-low versus API5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (API5→partner) and Y-score (partner→API5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP73 →	+0.520	+3.700	<.001	.005	3	3
BLCA	RN7SL371P →	+0.402	+4.746	<.001	.001	3	2
BLCA	OR10AE1P →	+0.046	+5.722	<.001	.001	3	2
LUAD	RN7SL649P →	+0.117	+4.197	<.001	.009	3	2
BRCA	HMGB3P23 →	+0.064	+5.054	<.001	.003	3	2
UCEC	BSG →	+0.367	+2.288	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

RNA5SP73 by API5 expression — LUAD

Explore this box plot interactively →