APH1B

Across TCGA pan-cancer cohorts, APH1B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated APH1B data layer compared with 26 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher APH1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated APH1B expression acts as an unfavorable survival marker.

BLCA and UCEC are the cancer types where APH1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.051	0.684	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

APH1B–BLCA (OS)

Open the BLCA breakdown →