APH1B

Across TCGA patient cohorts, APH1B mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible APH1B-associated genes across cancer lineages are ELOCP30, RNU6-693P, and TSPY12P. Each is linked with APH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both APH1B-to-partner and partner-to-APH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP30 grouped by APH1B-low versus APH1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1B→partner) and Y-score (partner→APH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELOCP30 →	+0.183	+3.937	<.001	.001	3	2
COAD	RNU6-693P →	+0.463	+5.721	<.001	.001	3	2
SKCM	TSPY12P →	+0.081	+6.219	<.001	<.001	3	2
SKCM	NREP-AS1 →	+0.050	+4.594	<.001	.008	3	2
BLCA	RNU6-666P →	+0.545	+6.814	<.001	<.001	3	2
BLCA	RNU1-57P →	+0.211	+7.040	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

ELOCP30 by APH1B expression — UCEC

Explore this box plot interactively →