APH1B

Across TCGA patient cohorts, APH1B mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APH1B-associated genes across cancer lineages are VEGFR2, PDK1_pS241, and AMPK_pT172. Each is linked with APH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both APH1B-to-partner and partner-to-APH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by APH1B-low versus APH1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1B→partner) and Y-score (partner→APH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.436	+2.820	.016	.036	2	1
UCEC	PDK1_pS241 →	+0.295	+2.820	.004	.036	1	1
UCEC	AMPK_pT172 →	+0.567	+2.820	.024	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

VEGFR2 by APH1B expression — UCEC

Explore this box plot interactively →