APEX1

Across TCGA patient cohorts, APEX1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,196 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible APEX1-associated proteins across cancer lineages are SSRP1, SUPT16H, and TRMT5. Each is linked with APEX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both APEX1-to-partner and partner-to-APEX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APEX1 versus SSRP1 in GBM, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APEX1→partner) and Y-score (partner→APEX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SSRP1 →	+0.554	+0.499	<.001	<.001	3	10
GBM	SUPT16H →	+0.532	+0.455	<.001	<.001	3	9
LSCC	TRMT5 →	+0.338	+0.361	<.001	<.001	3	8
GBM	ZC3H14 →	+0.314	+0.301	<.001	<.001	3	7
OV	IPO4 →	+0.467	+0.743	<.001	<.001	3	7
LSCC	NASP →	+0.530	+0.551	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,196 associations by consensus.

APEX1 vs SSRP1 — GBM

Explore this scatter interactively →