APELA

Across TCGA patient cohorts, APELA mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APELA-associated genes across cancer lineages are PEDS1-UBE2V1, SEPTIN14P19, and IGKV1OR-2. Each is linked with APELA in more than 1 cancer types. Because this analysis shows association rather than direction, both APELA-to-partner and partner-to-APELA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEDS1-UBE2V1 grouped by APELA-low versus APELA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APELA→partner) and Y-score (partner→APELA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEDS1-UBE2V1 →	+0.056	+3.943	<.001	.007	3	1
UCEC	SEPTIN14P19 →	+0.064	+5.660	<.001	.001	3	1
UCEC	IGKV1OR-2 →	+0.324	+4.393	.003	.002	3	1
UCEC	SERINC4 →	+0.017	+4.344	<.001	.002	3	1
UCEC	RNU6-770P →	+0.370	+4.430	.008	.002	3	1
UCEC	SNORD90 →	+0.568	+5.255	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PEDS1-UBE2V1 by APELA expression — UCEC

Explore this box plot interactively →