APELA

Across TCGA pan-cancer cohorts, APELA RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated APELA data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher APELA RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated APELA expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, KIRP, and ACC are the cancer types where APELA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.630	0.458	<.001	104	view →
KIRP	DFS	Quartile	II,III,IV	0.914	0.480	<.001	78	view →
ACC	DFS	Tertile	III,IV	0.145	0.531	.001	45	view →
BLCA	OS	Quartile	All	0.278	0.550	.003	33	view →
LUSC	OS	Quartile	II,III,IV	0.941	0.626	.011	26	view →
LUAD	OS	Median	II,III,IV	0.538	0.336	.006	25	view →
KIRC	OS	Median	All	0.565	0.679	.010	25	view →
COAD	OS	Median	IV	0.666	0.410	.009	24	view →
GBM	OS	Median	All	0.209	0.309	.004	18	view →
MESO	OS	Median	IV	0.765	0.357	.018	15	view →
UCS	DFS	Tertile	IV	0.829	0.321	.024	12	view →
TGCT	DFS	Tertile	All	0.588	0.753	.043	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

APELA–HNSC (DFS)

Open the HNSC breakdown →