APELA

Across TCGA cell cohorts, APELA RNA expression is significantly associated with the go_rna of many other GO terms, with 891 significant associations in total. BONE shows the largest number of these associations.

The most reproducible APELA-associated GO terms across cancer lineages are Regulation of plasminogen activation, Negative regulation of response to endoplasmic reticulum stress, and Positive regulation of G protein-coupled receptor internalization. Each is linked with APELA in more than 2 cancer types. Because this analysis shows association rather than direction, both APELA-to-partner and partner-to-APELA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by APELA-low versus APELA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APELA→partner) and Y-score (partner→APELA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasminogen activation →	-0.271	-1.719	<.001	.004	3	3
BONE	Negative regulation of response to endoplasmic reticulum stress →	-0.082	-1.621	.004	.004	3	3
BONE	Positive regulation of G protein-coupled receptor internalization →	-0.276	-2.480	<.001	<.001	3	3
BONE	Glial cell fate commitment →	+1.436	+2.080	<.001	<.001	3	3
BONE	Zymogen activation →	-0.298	-2.481	<.001	.001	3	3
BONE	Fibrinolysis →	-2.071	-2.641	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 891 associations by consensus.

Regulation of plasminogen activation by APELA expression — BONE

Explore this box plot interactively →