Across TCGA patient cohorts, APCS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,332 significant associations in total. PAAD shows the largest number of these associations.

The most reproducible APCS-associated GO terms across cancer lineages are Cellular glucuronidation, Cytolysis by host of symbiont cells, and Regulation of very-low-density lipoprotein particle remodeling. Each is linked with APCS in more than 9 cancer types. Because this analysis shows association rather than direction, both APCS-to-partner and partner-to-APCS results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APCS→partner) and Y-score (partner→APCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Cellular glucuronidation →	-0.096	-0.072	<.001	.006	1	10
SKCM	Cytolysis by host of symbiont cells →	-0.117	-0.171	<.001	<.001	3	7
HNSC	Regulation of very-low-density lipoprotein particle remodeling →	+0.737	+0.066	<.001	<.001	3	7
THCA	Glycine metabolic process →	-0.041	-0.042	<.001	.004	2	6
SKCM	Glycine biosynthetic process →	-0.050	-0.221	<.001	<.001	3	5
STAD	Steroid biosynthetic process →	+0.066	+0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,332 associations by consensus.

Exploration

APCS survival (RNA) · tumor vs normal (RNA) · all APCS data types