APCDD1L-DT

Across TCGA pan-cancer cohorts, APCDD1L-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated APCDD1L-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher APCDD1L-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APCDD1L-DT expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.

KIRC, MESO, and LUSC are the cancer types where APCDD1L-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.495	0.700	<.001	142	view →
MESO	OS	Tertile	All	0.322	0.671	<.001	129	view →
LUSC	OS	Median	All	0.599	0.738	<.001	99	view →
KIRP	DFS	Quartile	II,III,IV	0.097	0.661	<.001	88	view →
STAD	DFS	Median	All	0.324	0.627	<.001	64	view →
BLCA	OS	Quartile	All	0.313	0.563	.001	63	view →
LIHC	OS	Tertile	All	0.404	0.608	<.001	59	view →
LGG	DFS	Median	All	0.625	0.839	<.001	53	view →
CESC	DFS	Tertile	All	0.423	0.686	<.001	50	view →
THCA	OS	Quartile	All	0.870	0.979	.003	42	view →
SARC	DFS	Quartile	All	0.485	0.703	.001	34	view →
OV	DFS	Quartile	IV	0.270	0.585	.009	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

APCDD1L-DT–KIRC (DFS)

Open the KIRC breakdown →