APCDD1L-DT

Across TCGA pan-cancer cohorts, APCDD1L-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APCDD1L-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APCDD1L-DT RNA is repressed in tumor relative to normal tissue. In most cancer types APCDD1L-DT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where APCDD1L-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APCDD1L-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.669	<.001	12	view →
KIRP	Male	All	−2.098	<.001	11	view →
LUSC	Male	All	+0.596	<.001	8	view →
LUAD	All	All	+0.298	<.001	8	view →
KICH	Female	All	−1.747	<.001	7	view →
HNSC	Female	All	+0.871	.002	7	view →
BRCA	Female	All	−1.647	<.001	6	view →
LIHC	All	All	+0.022	.010	3	view →
PAAD	All	All	+2.022	.045	2	view →
UCEC	All	All	+0.522	.028	2	view →
PRAD	All	All	−0.071	.011	2	view →
CHOL	Female	All	+0.170	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APCDD1L-DT–KIRC

Open the KIRC breakdown →