APCDD1

Across TCGA cell cohorts, APCDD1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APCDD1-associated genes across cancer lineages are C9orf92, EPPIN, and OR3A1. Each is linked with APCDD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APCDD1-to-partner and partner-to-APCDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by APCDD1-low versus APCDD1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCDD1→partner) and Y-score (partner→APCDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.036	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	HIGD1C →	+0.108	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR1D4 →	+0.052	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

C9orf92 by APCDD1 expression — SOFT_TISSUE

Explore this box plot interactively →