APBB1IP

Across TCGA patient cohorts, APBB1IP mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB1IP-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Acetyl-a-Tubulin-Lys40. Each is linked with APBB1IP in more than 2 cancer types. Because this analysis shows association rather than direction, both APBB1IP-to-partner and partner-to-APBB1IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by APBB1IP-low versus APBB1IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB1IP→partner) and Y-score (partner→APBB1IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.356	+3.169	.001	.018	3	3
UCEC	Cyclin-B1 →	+0.608	+1.906	.007	.016	3	3
LUSC	Acetyl-a-Tubulin-Lys40 →	+0.790	+2.331	.005	.019	3	2
SKCM	eIF4E →	+0.166	+2.115	.016	.017	3	2
SKCM	N-Ras →	+0.125	+1.584	.018	.035	3	2
SKCM	PKC-delta_pS664 →	-0.163	-3.321	.025	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1 by APBB1IP expression — UCEC

Explore this box plot interactively →