APBB1IP

Across TCGA pan-cancer cohorts, APBB1IP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of APBB1IP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APBB1IP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APBB1IP is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where APBB1IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APBB1IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+3.205	<.001	12	view →
KIRP	Male	II,III,IV	+2.362	<.001	9	view →
COAD	Female	All	−0.960	<.001	9	view →
STAD	All	All	+1.113	.001	7	view →
LUSC	Male	All	−1.567	<.001	6	view →
BRCA	All	III,IV	−1.036	<.001	6	view →
LUAD	Male	All	−0.777	<.001	5	view →
KICH	All	II,III,IV	−1.078	.008	3	view →
BLCA	All	All	−0.821	.012	3	view →
PAAD	All	All	−2.120	.027	2	view →
ESCA	Male	All	+1.279	.009	2	view →
UCEC	All	All	−0.806	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

APBB1IP–KIRC

Open the KIRC breakdown →