APBA1

Across TCGA pan-cancer cohorts, APBA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated APBA1 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher APBA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated APBA1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where APBA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.660	0.962	.004	23	view →
UCEC	OS	Tertile	III,IV	0.511	1.000	.030	12	view →
LUAD	OS	Quartile	III,IV	0.719	0.285	.030	4	view →
HNSC	OS	Median	II,III,IV	1.000	0.939	.043	2	view →
GBM	DFS	Tertile	All	0.826	0.630	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

APBA1–LSCC (OS)

Open the LSCC breakdown →