APBA1

Across TCGA pan-cancer cohorts, APBA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of APBA1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where APBA1 RNA is repressed in tumor relative to normal tissue. In most cancer types APBA1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where APBA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APBA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.002	<.001	11	view →
COAD	Female	IV	−2.079	<.001	10	view →
KICH	Female	All	−1.170	<.001	10	view →
LUAD	All	III,IV	+0.609	<.001	8	view →
BLCA	Male	All	−0.592	.002	7	view →
HNSC	All	III,IV	+0.554	.003	7	view →
UCEC	All	III,IV	−1.286	<.001	6	view →
BRCA	Female	II,III,IV	−1.142	<.001	6	view →
READ	All	II,III,IV	−1.027	.003	4	view →
CHOL	All	II,III,IV	−1.130	.001	2	view →
PRAD	All	All	+0.425	<.001	2	view →
LUSC	All	All	+0.294	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

APBA1–THCA

Open the THCA breakdown →