APBA1

Across TCGA patient cohorts, APBA1 mutation is significantly associated with the RNA expression of many other genes, with 5,782 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBA1-associated genes across cancer lineages are CTDNEP1, ENO1, and CCT5. Each is linked with APBA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both APBA1-to-partner and partner-to-APBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTDNEP1 grouped by APBA1-low versus APBA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA1→partner) and Y-score (partner→APBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTDNEP1 →	+0.303	+1.787	<.001	<.001	3	4
SKCM	ENO1 →	+0.527	+1.931	<.001	.001	3	4
UCEC	CCT5 →	+0.481	+3.054	.001	<.001	3	3
UCEC	SUPV3L1 →	+0.388	+1.765	<.001	<.001	3	3
UCEC	CCNB2 →	+0.640	+1.999	<.001	<.001	3	3
UCEC	MED27 →	+0.396	+3.084	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,782 associations by consensus.

CTDNEP1 by APBA1 expression — UCEC

Explore this box plot interactively →