APBA1

Across TCGA patient cohorts, APBA1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBA1-associated genes across cancer lineages are ASNS, 4E-BP1, and Cyclin-B1. Each is linked with APBA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBA1-to-partner and partner-to-APBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by APBA1-low versus APBA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA1→partner) and Y-score (partner→APBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.537	+2.008	<.001	.018	3	3
UCEC	4E-BP1 →	+0.271	+3.807	.002	<.001	3	3
UCEC	Cyclin-B1 →	+0.732	+2.000	<.001	<.001	3	3
COAD	MIG-6 →	+0.104	+2.760	.008	.002	3	3
SKCM	PAI-1 →	+0.750	+1.891	.001	.027	3	2
UCEC	EGFR_pY1068 →	-0.242	-1.716	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ASNS by APBA1 expression — COAD

Explore this box plot interactively →