APBA1

Across TCGA cell cohorts, APBA1 mutation is significantly associated with the RNA expression of many other genes, with 1,593 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APBA1-associated genes across cancer lineages are GOT2, SRD5A2, and CBY1. Each is linked with APBA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBA1-to-partner and partner-to-APBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT2 grouped by APBA1-low versus APBA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA1→partner) and Y-score (partner→APBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GOT2 →	+0.490	+2.459	.008	.006	3	3
STOMACH	SRD5A2 →	+0.138	+3.632	<.001	.009	3	2
LARGE_INTESTINE	CBY1 →	+0.683	+3.482	<.001	<.001	3	2
LARGE_INTESTINE	YWHAE →	+0.561	+2.628	.002	.002	3	2
LARGE_INTESTINE	RIC8B →	+0.468	+2.628	.004	.002	3	2
LARGE_INTESTINE	WRAP73 →	+0.723	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,593 associations by consensus.

GOT2 by APBA1 expression — LARGE_INTESTINE

Explore this box plot interactively →