AP5Z1

Across TCGA cell cohorts, AP5Z1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,444 significant associations in total. CNS shows the largest number of these associations.

The most reproducible AP5Z1-associated GO terms across cancer lineages are Retrograde transport, endosome to Golgi, Negative regulation of autophagy, and Cytosolic transport. Each is linked with AP5Z1 in more than 15 cancer types. Because this analysis shows association rather than direction, both AP5Z1-to-partner and partner-to-AP5Z1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retrograde transport, endosome to Golgi grouped by AP5Z1-low versus AP5Z1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5Z1→partner) and Y-score (partner→AP5Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Retrograde transport, endosome to Golgi →	+0.075	+1.026	<.001	<.001	3	16
OESOPHAGUS	Negative regulation of autophagy →	+0.076	+0.935	<.001	<.001	3	15
BONE	Cytosolic transport →	+0.070	+0.970	.009	.003	3	15
LIVER	Protein localization to endosome →	+0.166	+1.284	.001	<.001	3	15
BONE	Pre-mRNA catabolic process →	+0.198	+0.735	.003	.009	3	14
OESOPHAGUS	Maintenance of unfolded protein →	+0.146	+1.050	.002	<.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,444 associations by consensus.

Retrograde transport, endosome to Golgi by AP5Z1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →