AP5Z1

Across TCGA pan-cancer cohorts, AP5Z1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated AP5Z1 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher AP5Z1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP5Z1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

KIRC, KICH, and LIHC are the cancer types where AP5Z1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.754	0.849	<.001	126	view →
KICH	OS	Tertile	All	0.484	1.000	<.001	91	view →
LIHC	DFS	Median	All	0.452	0.624	<.001	86	view →
MESO	DFS	Quartile	All	0.208	0.450	.002	67	view →
COAD	DFS	Tertile	All	0.624	0.768	.004	39	view →
ACC	DFS	Quartile	All	0.245	0.784	<.001	38	view →
LGG	DFS	Median	All	0.258	0.521	<.001	37	view →
SCLC	OS	Median	All	0.452	0.250	.017	31	view →
PAAD	OS	Tertile	All	0.519	0.295	.008	26	view →
UCS	DFS	Median	II,III,IV	0.200	0.502	.021	24	view →
UVM	DFS	Tertile	II,III,IV	0.569	0.947	.016	23	view →
CESC	OS	Median	III,IV	0.633	0.862	.007	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

AP5Z1–KIRC (DFS)

Open the KIRC breakdown →