AP5Z1

Across TCGA cell cohorts, AP5Z1 mutation is significantly associated with the RNA expression of many other genes, with 419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP5Z1-associated genes across cancer lineages are TAAR6, TAAR1, and HIPK4. Each is linked with AP5Z1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5Z1-to-partner and partner-to-AP5Z1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR6 grouped by AP5Z1-low versus AP5Z1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5Z1→partner) and Y-score (partner→AP5Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAAR6 →	+0.006	+2.922	.003	.009	3	1
BLOOD_Leukemia	TAAR1 →	+0.014	+2.922	<.001	.009	3	1
BLOOD_Leukemia	HIPK4 →	+0.039	+3.359	.009	.006	3	1
BLOOD_Leukemia	UCMA →	+0.066	+2.604	<.001	.006	3	1
BLOOD_Leukemia	PLA2G1B →	+0.279	+3.584	.007	.004	3	1
BLOOD_Leukemia	DPRX →	+0.057	+3.153	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 419 associations by consensus.

TAAR6 by AP5Z1 expression — BLOOD_Leukemia

Explore this box plot interactively →