AP4S1

Across TCGA patient cohorts, AP4S1 protein abundance is significantly associated with the protein abundance of many other proteins, with 10,057 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AP4S1-associated proteins across cancer lineages are AP4E1, SEC23B, and STRN3. Each is linked with AP4S1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AP4S1-to-partner and partner-to-AP4S1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AP4S1 versus AP4E1 in OV, with a Pearson correlation of 0.34.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4S1→partner) and Y-score (partner→AP4S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AP4E1 →	+0.340	+0.323	<.001	<.001	3	4
LSCC	SEC23B →	-0.205	-0.179	<.001	<.001	3	3
LUAD	STRN3 →	+0.212	+0.292	<.001	<.001	3	3
BRCA	STRN3_S229 →	+0.574	+0.424	<.001	<.001	3	3
LSCC	BAZ2A_S1207 →	-0.492	-0.245	.003	<.001	3	3
COAD	FKBP3 →	+0.398	+0.318	.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,057 associations by consensus.

AP4S1 vs AP4E1 — OV

Explore this scatter interactively →