AP4E1

Across TCGA patient cohorts, AP4E1 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,291 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible AP4E1-associated proteins across cancer lineages are RSF1, SMARCC2, and AMPD3. Each is linked with AP4E1 in more than 6 cancer types. Because this analysis shows association rather than direction, both AP4E1-to-partner and partner-to-AP4E1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AP4E1 versus RSF1 in GBM, with a Pearson correlation of -0.49.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4E1→partner) and Y-score (partner→AP4E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RSF1 →	-0.377	-0.212	<.001	<.001	3	6
UCEC	SMARCC2 →	-0.240	-0.175	<.001	<.001	3	6
GBM	AMPD3 →	+0.554	+0.189	<.001	<.001	3	6
HNSC	AP4B1 →	+0.247	+0.242	<.001	<.001	3	6
BRCA	ING4 →	-0.382	-0.169	.002	.001	3	6
CCRCC	AP4M1 →	+0.266	+0.242	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,291 associations by consensus.

AP4E1 vs RSF1 — GBM

Explore this scatter interactively →